Glucose and Fat Metabolism in Narcolepsy: Effect of Sodium Oxybate
نویسندگان
چکیده
795 Glucose and Fat Metabolism in Narcolepsy—Donjacour et al INTRODUCTION Narcolepsy is a sleep disorder that is characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucinations, sleep paralysis, disturbed nocturnal sleep and obesity.1 Both obesity and disturbed nocturnal sleep are important risk factors for the development of type 2 diabetes mellitus (T2DM).2 Narcolepsy is caused by a loss of hypocretin (orexin) neurons in the hypothalamus.3,4 Hypocretins are neuropeptides known to be involved in sleep-wake regulation, feeding behavior as well as body weight and temperature regulation.5,6 Furthermore hypocretins are important hypothalamic regulators of glucose homeostasis. Disturbed activation of hypocretin neurons during sleep deprivation may lead to increased basal endogenous glucose production and a decreased insulin sensitivity in rats.7 Moreover, hypocretin deficiency leads to an age-related defective glucose tolerance and insulin resistance.8 Intracerebroventricular infusions of hypocretin-1 increase hepatic glucose GLUCOSE AND FAT METABOLISM IN NARCOLEPSY: EFFECT OF SODIUM OXYBATE
منابع مشابه
Effect of sodium oxybate on growth hormone secretion in narcolepsy patients and healthy controls.
Hypocretin deficiency causes narcolepsy and may affect neuroendocrine systems and body composition. Additionally, growth hormone (GH) alterations my influence weight in narcolepsy. Symptoms can be treated effectively with sodium oxybate (SXB; γ-hydroxybutyrate) in many patients. This study compared growth hormone secretion in patients and matched controls and established the effect of SXB admin...
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STUDY OBJECTIVES To evaluate the efficacy and side-effect profile of off-label sodium oxybate (gamma hydroxy butyrate) therapy in severe childhood narcolepsy-cataplexy. DESIGN Retrospective; chart review. SETTING A multidisciplinary tertiary sleep center. PATIENTS A group of eight children with severe narcolepsy-cataplexy diagnosed on the basis of clinical history, nocturnal polysomnograp...
متن کاملTreatment of Narcolepsy and other Hypersomnias of Central Origin An American Academy of Sleep Medicine Review
1.0 Introduction 1.1 Purpose 1.2 Causes of excessive sleepiness 2.0 Background 3.0 Methods 3.1 Literature search strategy 3.2 Evidence review 4.0 Results 4.1 Treatment of hypersomnia due to narcolepsy with or without cataplexy 4.1.1 Medications 4.1.1.1 Amphetamine, methamphetamine, dextroamphetamine methylphenidate, and related preparations 4.1.1.2 Modafinil and armodafinil 4.1.1.3 Sodium oxyba...
متن کاملAustralasian Sleep Association Position Statement and Guidelines, regarding the Use of Sodium Oxybate in the Treatment of Narcolepsy
Sodium oxybate, the sodium salt of gamma-hydroxybutyrate, is approved for use in a number of international jurisdictions for the excessive sleepiness and cataplexy associated with narcolepsy. Its use is supported by at least six randomised control trials, involving over 700 patients, where both efficacy and safety data are available. Post-marketing data from 15 countries involving approximately...
متن کاملA 12-month, open-label, multicenter extension trial of orally administered sodium oxybate for the treatment of narcolepsy.
OBJECTIVES To evaluate the long-term safety and efficacy of nightly sodium oxybate for the treatment of narcolepsy. DESIGN A multicenter, 12-month, open-label trial. PARTICIPANTS 118 narcolepsy patients previously enrolled in a 4-week double-blind sodium oxybate trial. INTERVENTIONS Patients were administered 6 g sodium oxybate nightly, taken in equally divided doses at bedtime and 2.5 to...
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